New research provides additional insight into human memory and offers hope in understanding emotional illnesses like schizophrenia.

A structural variation in a part of the brain may explain why some people are better than others at distinguishing real events from those they might have imagined or been told about, researchers have found. This may also have profound implications in psychotic disorders like schizophrenia.

Scientists at The University of Cambridge found that normal variation in a fold at the front of the brain called the paracingulate sulcus (or PCS) might explain why some people are better than others at accurately remembering details of previous events or whether the event was imagined or actually occurred. The research was published in the October 5, 2011 issue of the Journal of Neuroscience.

A Different Fold, A Different Memory

This brain variation, which is present in roughly half of the normal population, is one of the last structural folds to develop before birth and for this reason varies greatly in size between individuals in the healthy population. The researchers discovered that adults whose MRI scans indicated an absence of the PCS were significantly less accurate on memory tasks than people with a prominent PCS on at least one side of the brain.

The lead researcher, Dr Jon Simons from the University of Cambridge  said: “As all those who took part were healthy adult volunteers with typical educational backgrounds and no reported history of cognitive difficulties, the memory differences we observed were quite striking. It is exciting to think that these individual differences in ability might have a basis in a simple brain folding variation.

Implications for Schizophrenia

“Additionally, this finding might tell us something about schizophrenia, in which hallucinations are often reported whereby, for example, someone hears a voice when nobody’s there. Difficulty distinguishing real from imagined information might be an explanation for such hallucinations. For example, the person might imagine the voice but misattribute it as being real. PCS reductions have been reported in previous studies of schizophrenia, and our results are consistent with the idea that this structural variability might directly influence the functional capacity of surrounding brain areas and the cognitive abilities that they support.”

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The above story contains original content and information that is editorially adapted by The Healthy Mind staff from materials provided by University of Cambridge and EurekAlerts!

Image Source: Digitalbob8 (Creative Commons)